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. 2019 Nov 4;6(12):2384–2394. doi: 10.1002/acn3.50930

Figure 4.

Figure 4

(A) Percentage of spinal vs. bulbar onset for the four most prevalent groups. Note the high rate of patients with a P525L or frameshift/truncating mutation presenting with bulbar disease, whereas R521 carriers mostly show spinal disease course. (B) Median age of onset and (C) OTSE grouped by spinal or bulbar disease onset. FUS‐ALS patients with bulbar onset had a significantly lower age of onset and survival as revealed by Mann‐Whitney U test. (D) Median survival time for selected mutation carriers grouped by side of onset. *P < 0.05, ***P < 0.001.