Figure 8.

β1‐p.Arg85Cys does not modulate I_Na density or τ of inactivation. (A) Representative I_Na density traces; currents were evoked with a 50‐msec test pulse to 0 mv following a prepulse to − 120 mV. Top: Cells expressing hNa_v1.1 alone (eGFP only). Middle: Cells expressing hNa_v1.1 plus WT β1 subunits. Lower: Cells expressing hNa_v1.1 plus β1‐p.Arg85Cys subunits. All traces are shown at the same scale. (B) Mean transient I_Na density measured at the peak from currents represented in (A). (C) Mean persistent I_Na density measured as the average current of the last 2 msec of the current to 0 mV represented in (A). (D and E) I_Na inactivation was fit to a double exponential equation and the mean τ for the fast and slow components were plotted. n = 13 cells per condition; *P < 0.05. Error bars indicate mean ± standard error of the mean. *P < 0.05. [Correction added on 06 December 2019 after first online publication: Figure 8 has been updated.]