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. 2019 Nov 11;6(12):2354–2367. doi: 10.1002/acn3.50921

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© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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WT β1 subunit co‐expression increases hNa_v1.1 I_Na density but neither WT β1 nor β1‐p.Arg85Cys affect the voltage dependence of hNa_v1.1‐generated I_Na. (A) Mean current‐voltage relationships of transient I_Na: hNa_v1.1 alone, tranfected with eGFP only, (open circles, n = 12 cells), hNa_v1.1 plus WT β1 (closed circles, n = 11 cells), hNa_v1.1 plus β1‐p.Arg85Cys (triangles, n = 13 cells). (B) Activation curves from the data shown in (A). (C). Steady‐state inactivation curves recorded using a standard two‐pulse protocol (hNa_v1.1, n = 12 cells; hNa_v1.1 plus WT β1, n = 13 cells; hNa_v1.1 plus β1‐p.Arg85Cys, n = 13 cells). [Correction added on 06 December 2019 after first online publication: Figure 9 has been updated.]