Table 1.
The 20 cases in which pathological diagnoses showed difference between local and central reviews
| Sample Name | Local Diagnosis | Central Diagnosis | Newly Found Components | Tx | HCG | AFP | Treatment Received | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Histology | Prognosis Group | Histology | Prognosis Group | Serum (IU/L) | CSF (IU/L) | Serum (ng/mL) | CSF (ng/mL) | Radiation | Chemotherapy (number of cycles) | |||
| GCT04 | Mixed GCT (ImT + YST + EC) | Poor | Mixed GCT (YST + EC + ImT + G) | Poor | G | No change | ND | ND | 2066 | ND | CSI+L | ICE (8) |
| GCT09 | Immature teratoma | Intermediate | Mixed GCT (ImT + G) | Intermediate | Good | ND | ND | 1492.5 | ND | L+ventricle | PE (8) | |
| GCT43 | Mixed GCT (G + CC + EC + MT) | Intermediate | Mixed GCT (G + ImT + CC + EC) | Intermediate | ImT | 9550 | ND | 316 | ND | CSI+L | ICE (8) | |
| GCT58 | Teratoma with malignant component | Intermediate | Mixed GCT (MT + G) | Intermediate | Good | ND | ND | ND | ND | EL | PE | |
| GCT61 | Teratoma | Intermediate | Mixed GCT (MT + G) | Intermediate | Good | ND | ND | 1.87 | ND | WBRT | PE | |
| GCT64 | Choriocarcinoma | Poor | Mixed GCT (MT + CC + G) | Intermediate (or Poor) | MT, G | 16632 | ND | ND | ND | CSI+EL | ICE | |
| GCT66 | Choriocarcinoma | Poor | Immature teratoma | Intermediate (or Poor) | ImT | 9359 | ND | 6.9 | ND | CSI+EL | ICE | |
| GCT70 | Mixed GCT (MT + G) | Intermediate | Mixed GCT (MT + G + Hemangioma) | Intermediate | Hemangioma | ND | <0.5 | ND | ND | WVI | ICE | |
| GCT73 | Choriocarcinoma | Poor | Mixed GCT (CC + G + ImT) | Poor | G, ImT | 9550 | ND | 317.2 | ND | ND | ND | |
| GCT77 | Yolk sac tumor | Poor | Mixed GCT (G + YST) | Intermediate (or Poor) | Good | ND | ND | 693.89 | 42.36 | CSI | ICE (4) | |
| GCT86 | Teratoma | Intermediate | Mixed GCT (MT + G + YST + EC) | Intermediate | G, YST, EC | ND | ND | 223 | ND | L | ICE (6) | |
| GCT90 | Germinoma | Good | Mixed GCT (MT + G) | Good | MT | <1.0 | ND | 1.2 | <0.4 | L | PE (5) | |
| GCT99 | Germinoma | Good | Germinoma with STGC | Intermediate | STGC | <1.0 | ND | <5.0 | ND | WVI | CARE (8) | |
| GCT113 | Embryonal carcinoma | Poor | Mixed GCT (EC + G) | Poor | Good | 39.2 | ND | <5.0 | ND | CSI+L | CARE (1), ICE (2) | |
| GCT153 | Mixed GCT (MT + YST + G) | Poor | Mixed GCT (ImT + YST + G) | Poor | ImT | 2.9 | 12.6 | ND | ND | WVI+L | PE (3) | |
| GCT155 | Immature teratoma | Intermediate | Mixed GCT (T + G) | Intermediate | Good | 92.8 | 33.4 | ND | ND | WVI+L | PE (3) | |
| GCT174 | Mixed GCT (EC + YST) | Poor | Mixed GCT (YST + EC + G) | Poor | Good | ND | ND | 70.4 | ND | ND | ICE (2) | |
| GCT176 | Immature teratoma | Intermediate | Mixed GCT (ImT + G) | Intermediate | Good | <2.0 | <2.0 | 372.8 | 20.2 | WVI+L | PE (3） | |
| GCT71 | Mature teratoma | Good | Teratoma with somatic-type malignancy (rhabdomyosarcoma) | Intermediate | Malignancy | Change | 35.7 | 76.3 | 21.4 | 0.4 | WBRT | ICE |
| GCT211 | Germinoma | Good | Immature teratoma | Intermediate | ImT | 4.9 | ND | ND | ND | EL | PE | |
Abbreviations: AFP: alpha fetoprotein; CARE: carboplatin + etoposide; CC: choriocarcinoma; CSF: cerebrospinal fluid; CSI: craniospinal irradiation; EC: embryonal carcinoma; EL: extended local radiation therapy; Good: good prognosis group; G: germinoma; GCT: germ cell tumor; HCG: human chorionic gonadotropin; Intermediate: intermediate prognosis group; ICE: ifosfamide + carboplatin + etoposide; ImT: immature teratoma; L: local radiation therapy; MT: mature teratoma; ND: no data; Poor: poor prognosis group; PE: cisplatin + etoposide; STGC: syncytiotrophoblastic giant cell; WBRT: whole brain radiation therapy; WVI: whole ventricular irradiation; YST: yolk sac tumor.