Comparison 1. Oral long‐chain omega‐3 PUFAs (ie, EPA and DHA) versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Dry eye symptoms, measured using the OSDI score [OSDI] units	4	677	Mean Difference (IV, Random, 95% CI)	‐2.47 [‐5.14, 0.19]
2 DESS: mean score at study endpoint [DESS units]	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
3 Schirmer test (tear production) (mm/5 min)	6	1826	Mean Difference (IV, Random, 95% CI)	0.68 [0.26, 1.09]
4 Tear break‐up time (TBUT) measured using fluorescein (seconds)	5		Mean Difference (IV, Random, 95% CI)	Subtotals only
5 Conjunctival impression cytology (CIC) score: mean score at study endpoint (Nelson grade)	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
6 Adverse event: gastrointestinal disorders	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only