Comparison 4. Oral long‐chain omega‐3 PUFAs versus oral omega‐6 PUFAs.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Dry eye symptoms, measured using the OSDI score [OSDI] units	2	130	Mean Difference (IV, Fixed, 95% CI)	‐11.88 [‐18.85, ‐4.92]
2 DESS: mean score at study endpoint [DESS units]	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3 Schirmer test (tear production) (mm/5 min)	4		Mean Difference (IV, Random, 95% CI)	Subtotals only
4 Tear break‐up time (TBUT) measured using fluorescein (seconds)	5		Mean Difference (IV, Random, 95% CI)	Subtotals only
5 Adverse event: gastrointestinal disorders	2	91	Risk Ratio (M‐H, Fixed, 95% CI)	2.34 [0.35, 15.54]