Table II.
Methods for pathogen reduction in blood components.
| Functional target | Method | Blood component | Usage |
|---|---|---|---|
| Lipids | Solvent and detergent treatment | Plasma | + |
|
| |||
| Nucleic acids | Photochemical treatment | ||
| Amotosalen + UVA light (Intercept®) | Plasma, platelets | +,+ | |
|
| |||
| Riboflavin + UVA/B light (Mirasol®) | Plasma, platelets, whole blood* | +, +, − | |
|
| |||
| Methylene-blue + visible light (Theraflex MB®) | Plasma | + | |
|
| |||
| Photo treatment | |||
| UVC light (Theraflex®) | Platelets | − | |
|
| |||
| Chemical treatment | |||
| Amustaline (S-303) and glutathione (Intercept RBC®) | Red blood cells* | − | |
*
methods under investigation, UV A: ultraviolet light wavelength 315–400 nm; UVB: ultraviolet light wavelength 280–315 nm; UVC: ultraviolet light wavelength 100–280 nm.