Table 3.

Medical and family history of LFS- or HBOC-related cancers in patients undergoing tumor-only NGS assay

Medical and family history of LFS-related cancersa	No. of patients with variants in TP53 (%)
	With possible SFs (n = 91)	Tested SangerSeq (n = 6)	With true SFs (n = 0)
In
P + FDR + SDR	0 (0)	0 (0)	0 (–)
P + FDR	4 (6.1)	0 (0)	0 (–)
P + SDR	0 (0)	0 (0)	0 (–)
P	2 (3.0)	0 (0)	0 (–)
FDR + SDR	0 (0)	0 (0)	0 (–)
FDR	4 (6.1)	0 (0)	0 (–)
LFS criteria matched	0 (0)	0 (0)	0 (–)

Medical and family history of HBOC-related cancersb	No. of patients with variants in BRCA1 or BRCA2 (%)
	With possible SFs (n = 11)	Tested SangerSeq (n = 3)	With true SFs (n = 3)
In
P + FDR + SDR	0 (0)	0 (0)	0 (0)
P + FDR	1 (9.1)	0 (0)	0 (0)
P + SDR	0 (0)	0 (0)	0 (0)
P	5 (45.5)	1 (33.3)	1 (33.3)
FDR + SDR	0 (0)	0 (0)	0 (0)
FDR	1 (9.1)	1 (33.3)	1 (33.3)
HBOC criteria matched	1 (9.1)	0 (0)	0 (0)

^aSarcoma, breast cancer, brain tumor, adrenocortical carcinoma, leukemia, or lung cancer

^bBreast cancer, ovarian cancer, prostate cancer, or pancreatic cancer

SFs secondary findings, LFS Li–Fraumeni syndrome, HBOC hereditary breast and ovarian cancer, P patient, FDR first degree relatives, SDR second degree relatives