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. 2019 Dec 11;10:2800. doi: 10.3389/fimmu.2019.02800

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Copyright © 2019 Ding, Song, Li, Chang, Pan, Gu, He and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of HON on body weight and food intake in HFD-fed mice. Mice were fed with a normal chow diet (ND), a high-fat diet (HFD), HFD plus HON at 200 (H200), 400 (H400), and 800 (H800) mg/kg BW for 8 weeks. Changes in the (A,B) body weight; (C) body weight gain; (D) total food intake; and (E) FER. Mean ± SE (n = 12). HON, honokiol. Statistically significance results between female and male treatment groups were expressed by lowercase letters (a, b, c) and uppercase letters (A, B, C) based on ANOVA with Duncan's range tests. Mean values with different letters indicate statistically significance results (P < 0.05). Statistically significant results in different sexes group are marked by ^*P < 0.05 and ^**P < 0.01.