Table 1.
Main miRNAs that regulate cellular metabolism in different types of cancer.
| miRNA | Location | Cancer type | Target gene/pathway | References |
|---|---|---|---|---|
| miR-125a | 19q13.41 | Hepatocellular carcinoma | HK2 | (152, 153) |
| miR-192/215-5p | 11q13.1, 1q41 | Colorectal cancer | ZEB1 and ZEB2, Type I collagens | (104) |
| miR-140-3p | 16q22.1 | Chronic myeloid leukemia | SIX | (154) |
| miR-140-3p | 16q22.1 | Spindle cell oncocytomas | TCA, carbohydrate, lipid metabolism | (155) |
| miR-940 | 16p13.3 | Glioma | MTHFD2 | (156) |
| miR-139-5p | 11q13.4 | Pediatric low-grade gliomas | PI3K/AKT signaling | (128) |
| miR-151a-5p | 8q24.3 | Malignant pleural mesothelioma | FASN, OXSM, ACACB | (157) |
| miR-361-5p | Xq21.2 | Prostate cancer | Sp1/PKM2 axis | (158) |
| miR-7, let-7a, miR-34a and miR-143 | 9q21.32, 9q22.32, 1p36.22; 1p36.22, 5q3 | Glioblastoma | Critical regulators of aerobic glycolysis | (159) |
| miR-125 | 19q13.41 | Hepatocellular carcinoma | HK2 | (160) |
| miR-122 | 18q21.31 | Hepatocellular carcinoma | PKM2 and represses glycolytic metabolism | (161) |
| miR-126 | 9q34.3 | Mesothelioma, hepatocellular, pancreatic and breast cancer | Insulin receptor substrate-1 (IRS1) | (134) |
| miR-195-5p | 17p13.1 | Bladder cancer | GLUT-3 | (59) |
| miR-155 | 21q21.3 | Breast cancer | miR-143 | (77) |
| miR-378 | 5q32 | Breast cancer | ERRγ and GABPA | (162) |