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. 2019 Dec 11;10:2862. doi: 10.3389/fimmu.2019.02862

Figure 10.

Figure 10

The effect of Mito-TEMPO on heat stress-induced pyroptosis in vivo. Mice with or without Mito-TEMPO (20 mg/kg) before heat stress; then spleen tissues were separated from mice 3 h after heatstroke. NLR pyrin domain containing 3 (NLRP3), caspase-1, gasdermin-D (GSDMD), and interleukin-1β (IL-1β) protein expression in spleen tissues measured by immunoblotting. Levels of NLRP3, caspase-1, GSDMD, and IL-1β protein expression are shown in the bar graph. Means and standard deviations are shown; results are representative of three separate independent experiments, n = 6 per group, **p < 0.01 compared with the control group (37°C), #p < 0.05, ##p < 0.01 compared with the sham heated group.