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. 2019 Dec 11;10:2839. doi: 10.3389/fmicb.2019.02839

FIGURE 2.

FIGURE 2

Comparative analysis of genes upregulated during intracellular survival and their presence/absence in non-classical Bordetella species. Analysis of protein similarity of (A) 318 B. bronchiseptica genes upregulated in macrophages and (B) 4,981 genes in the entire genome of B. bronchiseptica strain RB50 in comparison to the non-classical Bordetella species. From outside to inside: Circle 1: Virtual genome of B. bronchiseptica strain RB50. Circles 2–8: Visual representation of protein similarity between B. bronchiseptica RB50 and classical (circles 2–3) and the non-classical species (circles 4–8) represented as color shades with darker shades indicating higher protein similarity. (C) 77–81% of the genes upregulated in intracellular B. bronchiseptica were conserved among the non-classical species, (D) in contrast to only 46–55% of the 4,981 B. bronchiseptica genes in the entire genome. (E) Line plot showing the frequency of protein similarities.