TABLE 1.
Upregulated genes in intracellular B. bronchiseptica.
| Locus_tag | Gene | logFC | P-value | Description |
| DNA repair | ||||
| BB0180 | dksA | 3.8 | 2.4E-12 | RNA polymerase-binding transcription factor |
| BB1919 | dnaB | 1.4 | 5.4E-08 | Replicative DNA helicase |
| BB2076 | recA | 1.8 | 2.1E-08 | Recombinase RecA |
| BB2935 | dps | 2.0 | 2.0E-07 | Putative DNA-binding protein |
| Oxidative stress and pH homeostasis | ||||
| BB0020 | risA | 2.1 | 4.3E-06 | Transcriptional regulator RisA |
| BB1837 | rpoE | 3.2 | 1.7E-12 | RNA polymerase sigma factor RpoE |
| BB2275 | iscR | 4.2 | 1.7E-12 | Transcriptional regulator IscR |
| BB2276 | iscS | 2.5 | 3.3E-10 | Cysteine desulfurase |
| BB2279 | hscB | 1.6 | 1.5E-07 | HscB chaperone |
| BB2281 | fdx | 1.6 | 5.5E-04 | Ferredoxin, 2Fe–2S |
| BB3080 | slyA | 3.0 | 7.2E-06 | Transcriptional regulator SlyA |
| BB3766 | msrP | 1.6 | 8.7E-08 | Protein-methionine-sulfoxide reductase |
| BB3800 | msrB | 2.1 | 1.9E-07 | Peptide methionine sulfoxide reductase |
| BB4506 | rpoN | 3.4 | 9.5E-12 | Sigma(54) modulation protein RpoN |
| BB3942 | fur | 2.5 | 3.3E-08 | Ferric uptake regulator |
| BB4835 | rpoH | 4.5 | 2.4E-12 | RNA polymerase sigma factor RpoH |
| Protein folding | ||||
| BB0178 | hslU | 4.1 | 2.3E-12 | ATP-dependent protease |
| BB0179 | hslV | 6.0 | 1.9E-12 | ATP-dependent protease |
| BB0295 | secB | 1.6 | 1.3E-07 | Protein-export protein |
| BB0501 | htpG | 4.2 | 2.8E-10 | Chaperone protein |
| BB0962 | groEL | 4.4 | 8.4E-11 | 60 kDa chaperonin |
| BB0963 | groES | 7.8 | 6.7E-14 | 10 kDa chaperonin |
| BB2256 | 2.4 | 8.4E-11 | ATP-dependent protease | |
| BB3170 | hfq | 2.4 | 3.0E-07 | RNA-binding protein |
| BB3293 | clpB | 2.6 | 5.5E-10 | Chaperone protein |
| BB3933 | dnaJ | 1.7 | 1.1E-07 | Chaperone protein |
| BB3934 | dnaK | 3.9 | 9.7E-11 | Chaperone protein |
| BB3936 | grpE | 3.9 | 2.6E-10 | Chaperone protein |
| Metabolism | ||||
| BB0095 | glcB | 1.9 | 4.2E-06 | Malate synthase G |
| BB0096 | glcC | 1.9 | 1.5E-06 | Malate synthase G transcriptional regulator |
| BB3682 | sdhC | 2.3 | 1.0E-09 | Succinate dehydrogenase cytochrome B |
| BB3684 | mdh | 2.8 | 8.9E-10 | Malate dehydrogenase |
| BB1850 | acnB | 1.4 | 1.04.E-7 | Aconitate hydratase B |
| BB4150 | 2.4 | 1.5E-07 | Putative short-chain dehydrogenase | |
| BB3474 | ompA | 3.1 | 3.9E-11 | Outer membrane protein A |
| BB3759 | plsX | 1.6 | 1.9E-09 | Phosphate acyltransferase |
| BB3771 | pagL | 2.4 | 1.3E-08 | Lipid A deacylase |
| BB0233 | 2.9 | 2.3E-09 | Putative AMP-binding enzyme | |
| BB1556 | 4.1 | 2.4E-12 | ABC transporter, ATP-binding protein | |
| BB4592 | 4.1 | 1.7E-12 | Putative binding-protein-dependent transport | |
| BB0097 | 3.9 | 6.4E-10 | Putative dehydrogenase | |
| BB1446 | carA | 1.5 | 6.8E-09 | Carbamoyl-phosphate synthase |
| BB0235 | 5.1 | 9.5E-12 | Probable transporter | |
| BB4355 | argC | 2.6 | 5.4E-11 | N-acetyl-gamma-glutamyl-phosphate reductase |
| BB1986 | argG | 1.5 | 2.4E-08 | Argininosuccinate synthase |
| BB2000 | 2.5 | 1.3E-09 | Putative aldolase | |
| BB3179 | ndk | 2.3 | 1.9E-09 | Nucleoside diphosphate kinase |
| BB2607 | pyrH | 1.8 | 2.0E-09 | Uridylate kinase |
| BB3468 | cmk | 1.5 | 2.8E-08 | Cytidylate kinase |
| BB4376 | nrdA | 2.3 | 1.6E-09 | Ribonucleoside-diphosphate reductase |
| Virulence | ||||
| BB2992 | fimA | 2.6 | 9.7E-11 | Fimbrial protein |
| BB2994 | bvgA | 2.6 | 2.6E-09 | Transcriptional regulator of virulence |
| BB3424 | 1.7 | 3.7E-07 | Fimbrial protein | |
| BB3674 | fim2 | 6.7 | 1.7E-12 | Serotype 2 fimbrial subunit |
logFC, log2 fold change.