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. 2019 Dec 11;10:764. doi: 10.3389/fpsyt.2019.00764

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Copyright © 2019 Fusar-Poli, Davies, Solmi, Brondino, De Micheli, Kotlicka-Antczak, Shin and Radua

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example of sequential meta-analysis testing the preventive efficacy of CBT in CHR-P individuals. Plotted are the Randomized Controlled Trials of CBT vs Needs Based Intervention (NBI) in CHR-P patients that reported risk of psychosis onset at 6-month (part A) and 12 months (part B). The blue line represents the Z-value of each interim meta-analysis, the green line indicates the statistical significance threshold and the dotted red line the monitoring boundary. The red vertical line represents the a priori information size (APIS), i.e., the required sample size to detect a Relative Risk Reduction (RRR) = 0.5 with statistical power 0.9 on the risk of psychosis. Estimated using the package metacumbounds (101) and the previously published meta-analytical results (30).