Table 3.
Cases of total cancer and hazard ratios for the FH population compared with the control population, with stratification on age at baseline.
| Total study population | Women | Men | |||||
|---|---|---|---|---|---|---|---|
| Cases | HR (95% CI)* | p-value | Cases | HR (95% CI)* | Cases | HR (95% CI)* | |
| Age 0–39 | |||||||
| Control | 923 | 1 | 589 | 1 | 334 | 1 | |
| FH | 50 | 1.09 (0.82–1.44) | 0.57 | 28 | 0.95 (0.65–1.39) | 22 | 1.33 (0.87–2.05) |
| Age 40–69 | |||||||
| Control | 4050 | 1 | 1962 | 1 | 2088 | 1 | |
| FH | 203 | 0.95 (0.82–1.09) | 0.44 | 100 | 0.98 (0.80–1.20) | 103 | 0.91 (0.75–1.11) |
| Age 70+ | |||||||
| Control | 606 | 1 | 337 | 1 | 269 | 1 | |
| FH | 36 | 0.98 (0.70–1.37) | 0.90 | 20 | 0.99 (0.63–1.57) | 16 | 0.96 (0.58–1.60) |
*HR from Cox proportional hazards regression stratified on matched case set. FH, familial hypercholesterolemia; HR, hazard ratio; CI, confidence interval.