Table 4.
Cases of smoking-related cancer and hazard ratios for the FH population compared with the control population, with stratification on age at baseline.
| Total study population | Women | Men | |||||
|---|---|---|---|---|---|---|---|
| Cases | HR (95% CI)* | p-value | Cases | HR (95% CI)* | Cases | HR (95% CI)* | |
| Age 0–39 | |||||||
| Control | 262 | 1 | 153 | 1 | 109 | 1 | |
| FH | 14 | 1.07 (0.62–1.83) | 0.82 | 5 | 0.66 (0.27–1.60) | 9 | 1.63 (0.83–3.22) |
| Age 40–69 | |||||||
| Control | 1673 | 1 | 769 | 1 | 904 | 1 | |
| FH | 66 | 0.73 (0.57–0.94) | 0.01 | 32 | 0.79 (0.56–1.13) | 34 | 0.69 (0.49–0.97) |
| Age 70+ | |||||||
| Control | 285 | 1 | 163 | 1 | 122 | 1 | |
| FH | 17 | 0.95 (0.58–1.56) | 0.85 | 9 | 0.90 (0.46–1.77) | 8 | 1.02 (0.50–2.09) |
*HR from Cox proportional hazards regression stratified on matched case set. FH, familial hypercholesterolemia; HR, hazard ratio; CI, confidence interval.