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. 2019 Dec 17;9:19235. doi: 10.1038/s41598-019-55513-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of exome and transcriptome sequencing data between uveal melanomas and skin cutaneous melanomas. (a) Mutational signature analysis for primary uveal melanomas. (b) Mutational signature for primary skin cutaneous melanomas. (c,d) Gene Set Enrichment Analysis plots show upregulation of MYC signature genes in primary uveal melanomas when compared with skin cutaneous melanomas. The genes in the genesets are generated from primary epithelial breast cancer cell cultures over-expressing the MYC gene.