Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 17;10:5743. doi: 10.1038/s41467-019-12917-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Differentially expressed genes are revealed in rod and cone photoreceptors. a Gene ontology networks demonstrate the biological process GO terms enrichment by photoreceptor cell DEGs. All photoreceptor cell DEGs (177 genes) were used as input for the online software NetworkAnalyst⁷⁶ and only the terms with FDR adjusted p-value less than 0.05 were visualized. Terms were colored according to the p-value from low (red) to high (yellow). b Overlap of the hCOR (human cone-over-rod) and mCOR (mouse cone-over-rod) gene list and biological process GO term enriched in non-overlapping part. c Demonstration of the expression of CRD/LCA genes in the non-overlapping part of hCOR (AHI1, ATXN7, KCNV2, PROM1, RD3, RPGRIP1) and mCOR (GUCA1A). In the box plots, bounds of the box spans from 25 to 75% percentile, center line represents median, and whiskers visualize 1.5 times inter-quartile range less than quartile 1 or 1.5 times inter-quartile range more than quartile 3 of all the data points. d Immunofluorescent staining for RD3 and RHO on human retina cryosections. White triangles and arrows highlight the fluorescent signal of the cones and rods, respectively, in the top and bottom panel. Retinal cell layers are labeled in the bottom panel (OS outer segment, IS inner segment, ONL outer nuclear layer, OPL outer plexiform layer, INL inner nuclear layer, IPL inner plexiform layer, GCL ganglion cell layer). Scale bar is 20μm. e Immunofluorescent staining for RPGRIP1 and RHO on human retina cryosections. White triangles and arrows highlight the fluorescent signal of the cones and rods, respectively, in the top and bottom panel. Retinal cell layers are labeled in the bottom panel. Scale bar is 20μm.