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. 2019 Dec 17;10:5747. doi: 10.1038/s41467-019-13744-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — B16.OVA a Percentage of dendritic cells cross-presenting OVA (SIINFEKL) in the context of MHC class I in the tumor microenvironment, b OVA-specific, c OVA-specific antigen-experienced, and d antigen-experienced T cells in the tumor microenvironment. The number of T cells was normalized by the tumor volume. Mix identifies a treatment composed of cell membrane vesicles just mixed with adenovirus without extrusion. The results are presented as mean ± s.d (n ≥ 3) and the dot plot of the single replicates. The data were analyzed with a two-way ANOVA, followed by Dunnet (a–c) or Tukey (d) post-test comparison. The levels of significance were set at the probabilities of *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. B16F10 e CD11c⁺ dendritic cells percentage in the tumor microenvironment and f gp100 and g TRP2 pentamer-specific T-cells, identifying the CD8⁺ tumor-specific T-cells in the tumor microenvironment. h Antigen-experienced T-cells measured by the expression of PD-1 on T-cells. Mix identifies a treatment composed of cell membrane vesicles just mixed with adenovirus without extrusion. The data are presented as mean ± s.d (n ≥ 7), together with the dot plot of the single value. The data were analyzed with two-way ANOVA, followed by Fisher LSD post-test. The levels of significance were set at the probabilities of *p < 0.05, **p < 0.01. LL/2 i Percentage of CD11c⁺ dendritic cells in the tumor microenvironment in the LL/2 model. j Percentage of CD68⁺ macrophages. k Percentage of CD4⁺ and l CD8⁺ T-cells in the tumor microenvironment. Mix identifies a treatment composed of cell membrane vesicles just mixed with adenovirus without extrusion. The data are presented as mean ± s.d. (n = 4) and were analyzed by two-way ANOVA, followed by Dunnet’s post-test. The levels of significance were set at the probabilities of *p < 0.05 and **p < 0.01. The error bars represent s.d.