Table 3.
RT-PCR Analysis of Epithelial and Mesenchymal Transcripts.
| Control + Tx (±SEM, n) | Mutant + Tx (±SEM, n) | p value | |
|---|---|---|---|
| Lgr5-Epi | 0.2864 ± 0.07627, n = 9 | 0.0508 ± 0.01402, n = 10 | 0.0053** |
| Olfm4-Epi | 15.15 ± 4.903, n = 9 | 3.761 ± 1.336, n = 10 | 0.0311* |
| Tert-Epi | 0.2001 ± 0.03286, n = 8 | 0.07712 ± 0.01662, n = 7 | 0.0071** |
| HopX-Epi | 11.66 ± 2.426, n = 5 | 9.494 ± 2.167, n = 5 | 0.5245 |
| Lactase-Epi | 4.366 ± 1.627, n = 5 | 0.1924 ± 0.1606, n = 4 | 0.0587 |
| Muc2-Epi | 14.78 ± 4.279, n = 6 | 28.44 ± 18.41, n = 6 | 0.4866 |
| Lysozyme-Epi | 94.24 ± 46.41, n = 6 | 67.62 ± 39.26, n = 6 | 0.6709 |
| CgA-Epi | 2.54 ± 0.768, n = 9 | 0.6836 ± 0.0898, n = 10 | 0.0214* |
| NGN3-Epi | 1.852 ± 0.8388, n = 6 | 0.9663 ± 0.7061, n = 5 | 0.4514 |
| Gata4-Epi | 149.5 ± 1.190, n = 4 | 153.0 ± 2.041, n = 4 | 0.1891 |
| Gata6-Epi | 8.550 ± 0.08660, n = 4 | 8.333 ± 0.1202, n = 3 | ND |
| Ihh-Epi | 0.2412 ± 0.05371, n = 7 | 0.08471 ± 0.01031, n = 10 | 0.0039** |
| Patched1-Mes | 5.71 ± 1.578, n = 9 | 1.863 ± 1.002, n = 7 | 0.0755 |
| Abcg5-Epi | 4.400 ± 0.04082, n = 4 | 3.225 ± 0.3146, n = 4 | 0.0100* |
| Abcg8-Epi | 29.25 ± 2.136, n = 4 | 30.50 ± 3.122, n = 4 | 0.7523 |
| Ada-Epi | 35.88 ± 10.76, n = 6 | 36.81 ± 15.29, n = 6 | 0.9614 |
| Akr1b8-Epi | 23.75 ± 1.377, n = 4 | 61.75 ± 32.44, n = 4 | 0.2862 |
| Apoa4-Epi | 4.200 ± 0.3416, n = 4 | 5.125 ± 0.4366, n = 4 | 0.1462 |
| ApoB-Epi | 89.25 ± 8.240, n = 4 | 91.00 ± 16.68, n = 4 | 0.9281 |
| ApoC2-Epi | 50.03 ± 17.52, n = 6 | 83.5 ± 27.38, n = 6 | 0.3275 |
| ApoC3-Epi | 21.29 ± 7.974, n = 6 | 19.8 ± 8.618, n = 5 | 0.9019 |
| Asah2-Epi | 3.839 ± 1.392, n = 5 | 1.091 ± 0.4592, n = 4 | 0.1355 |
| Cck-Epi | 0.1250 ± 0.0250, n = 4 | 0.1000 ± 0.0, n = 4 | 0.3559 |
| CD36-Epi | 0.3076 ± 0.1051, n = 4 | 0.1526 ± 0.04739, n = 4 | 0.2274 |
| Cftr-Epi | 10.03 ± 1.854, n = 4 | 4.231 ± 0.4631, n = 5 | 0.0116* |
| Dnase1-Epi | 4.018 ± 1.422, n = 6 | 0.04963 ± 0.02351, n = 5 | 0.0325* |
| Enpp7-Epi | 0.1001 ± 0.02252, n = 4 | 0.009414 ± 0.007271, n = 3 | ND |
| Fabp2-Epi | 116.5 ± 0.9574, n = 4 | 120.3 ± 2.016, n = 4 | 0.1438 |
| Hsd17b6-Epi | 7.889 ± 2.534, n = 5 | 3.785 ± 2.251, n = 4 | 0.2778 |
| Pdx1-Epi | 2.025 ± 0.04787, n = 4 | 1.525 ± 0.1377, n = 4 | 0.0140* |
| Slc2a1-Epi | 2.236 ± 0.7246, n = 5 | 4.314 ± 0.5867, n = 5 | 0.0564 |
| Slc2a2-Epi | 53.50 ± 4.592, n = 4 | 55.50 ± 4.113, n = 4 | 0.7566 |
| Slc2a5-Epi | 9.925 ± 0.3224, n = 4 | 8.925 ± 0.5154, n = 4 | 0.1511 |
| Slc2a8-Epi | 0.3324 ± 0.08289, n = 4 | 0.5209 ± 0.3911, n = 5 | 0.6875 |
| Slc5a1-Epi | 15.69 ± 4.248, n = 5 | 6.339 ± 2.323, n = 4 | 0.1170 |
| Slc5a11-Epi | 1.191 ± 0.2438, n = 4 | 0.1546 ± 0.1244, n = 4 | 0.0091** |
| Sst-Epi | 0.1750 ± 0.0250, n = 4 | 0.1000 ± 0.0, n = 4 | 0.0240* |
| Ugt2a3-Epi | 6.886 ± 1.61, n = 5 | 3.701 ± 1.32, n = 5 | 0.1646 |
* Indicates p < 0.05 and ** Indicates p < 0.01.