Table 1.

Estimated model parameters obtained from the least squares fitting for the ODE model shown in Fig. 3b.

Parameters	Values		Error	Units
αU	0.60	±	0.01	s−1
αV	2.75 × 10−5	±	8.35 × 10−7	s−1
αV+	0.51	±	0.0123	s−1
αW	3.68 × 10−7	±	9.76 × 10−9	s−1
αW+	0.78	±	0.0013	s−1
δU	0.00501	±	7.23 × 10−5	s−1
δV	0.00026	±	2.57 × 10−6	s−1
δW	0.00109	±	3.05 × 10−6	s−1
βX	0.00046	±	1.41 × 10−5	s−1
βY	0.0018	±	4.10 × 10−5	s−1
βZ	0.00098	±	1.53 × 10−6	s−1
κ	8.99 × 104	±	8.88 × 102	M−1 s−1
κi	1.0 × 10−4	±	1.42 × 10−6	s−1
ω	8.02 × 105	±	7.34 × 103	M−1 s−1
ν	1.54	±	0.07	s−1
ϒG	1.95 × 10−3	±	4.86 × 10−6	s−1

Note for the open-loop response α_V, α_V⁺, δ_V, β_Y, κ, κ_i, and P_Y^tot were set to zero. The error values were determined using the standard error of the mean. N = 1000