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. 2019 Dec 17;9:19291. doi: 10.1038/s41598-019-55132-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of hiNPC on sensory function following T3SCI. (a) Hindpaw tactile allodynia was studied from 8 to 16 weeks post-T3SCI. (n.s., by two-way repeated measures ANOVA followed by Bonferroni post-hoc analysis mean ± SEM; n = 4–6 rats per group). (b) Heat map of differentially abundant transcripts by RNA-Seq in L5 DRGs after T3SCI, with and without grafted hiNPC. Increased expression is shown in red and reduced expression is shown in blue. RNA-Seq transcripts and experimental groups are arranged by unsupervised hierarchical clustering. Genes in bold are of potential interest for future pain related studies. (c) Changes in expression of KCNN1 and VIP in L5 DRGs at 8 and 16 weeks post-T3SCI (*P < 0.05 by Students t-test, mean ± SEM; n = 2–3). (d) Forepaw tactile withdrawal thresholds from 8–16 weeks (n.s., two-way repeated measures ANOVA followed by Bonferroni post-hoc analysis, mean ± SEM; n = 4–6 rats per group).