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. 2019 Dec 17;9:19295. doi: 10.1038/s41598-019-55675-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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I8-arachnotocin is an agonist at human V₂R, V_1bR, and OTR. Concentration-dependent accumulation of second messengers (cAMP and IP₁) after receptor stimulation of (a) OTR, (b) V_1aR, (c) V_1bR and (d) V₂R with I8-arachnotocin (30 pM – 30 µM). Results were normalized to accumulation of IP₁ and cAMP above baseline and maximal activation of the receptors by their endogenous ligands (OT for OTR and VP for VPRs). Data points were fitted by nonlinear regression curves (sigmoidal, slope = 1); error bars depict SEM; n = 3. For EC₅₀ and E_max values refer to Table 1.