Table 1.

Potency and efficacy (G protein-mediated) of I8-arachnotocin at human receptors.

	I8-arachnotocin			VP/OT&
	EC50	pEC50	Emax#	EC50	pEC50	Emax#
V2R	34 nM	−7.47 ± 0.09	99 ± 3%	6.7 pM	−11.17 ± 0.10	100%
V1bR	1.2 µM	−5.93 ± 0.15	104 ± 8%	1.6 nM	−8.80 ± 0.09	100%
V1aR	antagonist pA2 of 6.253 (~558 nM)			0.56 nM	−9.25 ± 0.07	100%
OTR	790 nM	−6.11 ± 0.20	62 ± 6%	12 nM	−7.91 ± 0.09	100%

^#EC₅₀ is given in nM or µM (as indicated) and as pEC₅₀ as logEC₅₀ ± SEM.

^&controls were VP at V₂R, V_1aR, V_1bR and OT at OTR.