Table 2.

Potency and efficacy (β-arrestin recruitment) of I8-arachnotocin at human receptors.

	I8-arachnotocin			OT/VP&
	EC50	pEC50	Emax#	EC50	pEC50	Emax#
V2Rβ-arr1	n.d.			56 nM	−7.25 ± 0.07	100%
V2Rβ-arr2	n.d.			60 nM	−7.22 ± 0.07	100%
V1bR	1.2 µM	−5.92 ± 0.14	65 ± 5%	6.9 nM	−8.16 ± 0.09	100%
V1aR	n.d.			28 nM	−7.55 ± 0.12	100%
OTR	5.7 µM	−5.24 ± 0.26	32 ± 5%	170 nM	−6.77 ± 0.15	100%

^#EC₅₀ is given in nM or µM (as indicated) and as pEC₅₀ as logEC₅₀ ± SEM.

^&controls were VP at V₂R, V_1aR, V_1bR and OT at OTR; n.d., not detectable; β-arr, β-arrestin.