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. 2019 Dec 17;10:5754. doi: 10.1038/s41467-019-13623-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative immunofluorescent images of DGC complex and glycosylation form of α-DG in control (floxed) and MCK-Fktn-cKO hearts. Anti-IIH6 (glycosylated form of αDG), βDG, dystrophin (Dys), αSG, βSG, and γSG antibodies (green) and DAPI (blue). Scale bar, 10 μm. b Cardiac morphology in floxed and MCK-Fktn-cKO mice. Scale bar, 5 mm. c Heart weight-to-body weight ratios (HW/BW) (n = 9 mice per group). d Masson’s trichrome staining of the left ventricle. Scale bar, 50 μm. Cross-sectional areas (6w, n = 259 and 268 cells; 16w, n = 303 and 311 cells; 24w, n = 266 and 287 cells; 48w, n = 283 and 256 cells measured from 3 hearts per group.) (e) and fibrosis percentages (n = 3 mice per group) (f) from paraffin sections of left ventricles. Echocardiographic parameters of left ventricle diastolic dimension (g) and fractional shortening (h) in floxed and MCK-Fktn-cKO mice (n = 12 mice per group). Data are means ± s.e.m; #P < 0.05 between indicated groups based on Student’s t-tests.