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. 2019 Dec 17;10:5754. doi: 10.1038/s41467-019-13623-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — a Microarray analysis using floxed and αMHC-MCM-Fktn-cKO (Fktn^flox/flox; αMHC-MCM^+/−) hearts treated with tamoxifen for 4 d. Heat map displaying hierarchical clustering and expression levels of differentially expressed Golgi apparatus-related genes. b Volcano plot of upregulated or downregulated genes in tamoxifen-treated αMHC-MCM-Fktn-cKO (Fktn^flox/flox; αMHC-MCM^+/−) hearts. Dots indicating Pde4dip, Pcnt, and Clasp are overlapping. c Gene set enrichment analysis revealing enriched pathways and processes in tamoxifen-treated αMHC-MCM-Fktn-cKO hearts. d Significantly enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) categories show differentially expressed gene pathways in tamoxifen-treated αMHC-MCM-Fktn-cKO hearts. e Representative immunofluorescence images of neonatal cardiomyocytes cultured with FCS (Core DG, green; Rab3a, red; DAPI, blue). Scale bar, 50 μm. f Representative immunofluorescence images of HEK, FKTN-KO HEK, and HEK expressing full-length DG (Core DG, green; Rab3a, red; DAPI, blue (left panels); Core DG, green; GM130, red; DAPI, blue (right panels)). Scale bar, 50 μm.