Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 17;10:5754. doi: 10.1038/s41467-019-13623-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a Cardiac morphology and histology following isoproterenol (Iso) or phenylephrine (PE) administration or thoracic aortic constriction (TAC) for 2 weeks in control (floxed) and MCK-Fktn-cKO mice. Scale bar, 5 mm (top) and 50 μm (bottom). b Heart weight-to-body weight ratios (HW/BW) (n = 9 mice per group). Cross-sectional areas (vehicle, n = 252 cells; +Iso, n = 283 cells; +PE, n = 249 cells; TAC, n = 264 cells from 3 control (floxed) mice. Vehicle, n = 315 cells; +Iso, n = 250 cells; +PE, n = 229 cells; TAC, n = 274 cells from 3 MCK-Fktn-cKO mice) (c) and fibrosis percentages (n = 3 mice per group) (d) from paraffin sections of left ventricles. e Fractional shortening in hearts of treated and untreated control (n = 12 mice per group). *P < 0.05 vs. vehicle-treated floxed mice; #P < 0.05 between indicated groups based on Tukey–Kramer tests. f Representative immunoblots for total and phosphorylated Akt, CamKII, PKD, and HDAC9 levels in control and MCK-Fktn-cKO mice after Iso (or vehicle) treatment. GAPDH was used for a loading control (n = 6 per group). *P < 0.05 vs. vehicle-treated floxed mice; ^#P < 0.05 between indicated groups based on Tukey–Kramer tests.