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. 2019 Dec 17;9:19233. doi: 10.1038/s41598-019-55882-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dietary fatty acids in normolipidic diets modulate the immune system and inflammation in the mouse VP. C57/BL6 mice were fed the specified diets for 32 weeks and the VP transcriptome was examined by RNAseq. Principal component analysis (PCA) segregated the PF results from the other two groups, which were segregated by the second component. (a) The number of genes differentially expressed in the different groups are presented as Venn diagrams. (b) Biological processes and molecular functions affected by the different diets are shown in (c,d) according to their significance; bars represent the p-values and dots represent the ratios between the number of genes differentially expressed and the total number of annotated genes (enrichment) within each ontology. Genes differentially expressed were represented in Volcano plots in a pair-wise format; the graphs show each gene’s expression (Log2 fold change) and the corresponding p-value for each pair-wise comparison. Genes related to protein localization/targeting to the EA, ER stress and fatty acid biosynthesis were also represented in a heatmap (e–i), using normalized expression values (Z-Score) for each gene (n = 5).