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. 2019 Dec 17;9:19242. doi: 10.1038/s41598-019-55805-4

Figure 1.

Figure 1

Structure and C-region sequences of Abs. (a) Schematic representation of mouse IgG, chimeric MH-IgG (mouse V region with human C regions), and chimeric MC-IgY (mouse V region with chicken C regions). (b) Ab sequence alignment. Sequences of constant regions derived from different species were aligned using the Clustal Omega server (https://www.ebi.ac.uk/Tools/msa/clustalo/). Asterisks (*) indicate the positions of single fully conserved residues; colons (:) indicate conservation between groups of highly similar properties (score > 0.5 using the Gonnet PAM 250 matrix); periods (.) indicate conservation between groups of weakly similar properties (score ≤ 0.5 using the Gonnet PAM 250 matrix).