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. 2019 Dec 17;9:19247. doi: 10.1038/s41598-019-55643-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FGF21 is required to enhance sympathetic activity and suppress parasympathetic activity in CKD. The sympathetic activity (LF and LF/HF) and the parasympathetic activity (HF) during physical activity in the nighttime (a, c, e) and in the daytime (b, d, f) were calculated in wild-type control mice, wild-type CKD mice, Fgf21^−/− control mice, Fgf21^−/− CKD mice, wild-type mice injected with the AAV8-LacZ vector (LacZ) and wild-type mice injected with the AAV8-FGF21 vector (FGF21). The bars indicate mean ± SD, **P < 0.01, *P < 0.05 by t-test.