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. 2019 Dec 17;9:19247. doi: 10.1038/s41598-019-55643-4

Figure 6.

Figure 6

FGF21 activates NTS neurons and may suppress baroreflex. (a) Correlation between serum FGF21 levels and baroreflex sensitivity by Pearson correlation coefficient in 184 CKD patients. Adjusted for age and sex. Immunohistochemistry of the NTS region after intracerebroventricular injection of 0 ng (b), 10 ng (c), 100 ng (d), and 1000 ng (e) of FGF21. Bar = 100 mm. (f) The number of c-Fos positive cells was increased in an FGF21 dose-dependent manner. P < 0.0001 by one-way ANOVA.