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. 2019 Dec 17;9:19276. doi: 10.1038/s41598-019-55694-7

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© The Author(s) 2019, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Compared to the vesicle secreted protein database, MS analysis using FunRich³² analysis tool identified a number of similar and unique proteins secreted in MSC exosomes (A). Proteomic analysis identified different transcription factors in MSC exosomes (B). FunRich analysis revealed the different pathways which the secreted proteins modulate (C) and the processes which the exosomal proteins regulate (D). IPA analysis revealed the many this exosomal cargo modulates cellular proliferation, cell survival, and in recipient cells.