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. 2019 Dec 17;9:19276. doi: 10.1038/s41598-019-55694-7

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© The Author(s) 2019, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MS analysis of cardiomyocytes (CMs) using FunRich³² analysis tool: Differences in response to exosome treatment in cells can be attributed to the functional exosomal cargo in regulating gene expression such as changes in (A) expression of transcription factors (TFs) in LPS stressed cells or (B) LPS treated cells rescued by MSC exosomes. (C) Analysis of biological processes of proteins identified by MS in exosome rescued cardiomyocytes post LPS treatment. The processes presented are in comparison against LPS stimulated cardiomyocytes.