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. 2019 Dec 17;9:19276. doi: 10.1038/s41598-019-55694-7

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© The Author(s) 2019, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network analysis: IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis)³³ network analysis revealed upregulated signaling networks leading to cardiomyocytes death and cardiac fibrosis (A) and suppressed pathways leading to proliferation of cardiomyocytes, autophagy and fibroblast cell death (B). Exosome treatment of LPS stimulated cells upregulated signaling networks leading to increased cell viability and cell survival (C) while it decreased apoptotic signaling network (D).