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. 2019 Dec 17;9:19276. doi: 10.1038/s41598-019-55694-7

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© The Author(s) 2019, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MSC Exosomes provide significant cardioprotection against LPS stimulated stress responses. LPS treatment significantly increases pro-inflammatory LOX-1 expression along with cleaved caspase-3, and LC3. In spite of presence of LPS and continued stimulation of TLR4 LPS receptors, addition of MSC exosomes reverses the effects of LPS by downregulating expression of LOX-1, caspase-3 and LC3, thereby decreasing apoptosis and autophagy.