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. 2019 Dec 17;9:19313. doi: 10.1038/s41598-019-55571-3

Table 3.

Overview of the effects of covariates on cortisol and cortisone levels.

Time of measurement after awakening AUCg AUCi
0 min 15 min 30 min
Cortisol
Working day −0.83 (0.32)* 0.49 (0.35) −0.92 (0.4)* −1.35 (0.57)* 0.27 (0.56)
Duration of sleep 0.15 (0.14) 0.2 (0.15) 0.23 (0.18) 0.43 (0.26) 0.02 (0.26)
Time of awakening −0.24 (0.12)* −0.36 (0.12)** −0.42 (0.12)** −0.6 (0.18)** 0.12 (0.18)
Medication use 0.86 (0.46) 0.88 (0.52) 1.65 (0.66)* 2.55 (0.89)** 0.74 (0.9)
Smoking 1.11 (0.59) −1.47 (0.6)* 1.86 (1.07) −2.97 (1.13)* 0.72 (1.38)
Sex 0.46 (0.45) 0.24 (0.52) 0.02 (0.88) 0.48 (1.01) 0.42 (1.04)
Age 0.04 (0.05) 0.006 (0.06) 0.03 (0.1) 0.003 (0.12) 0.08 (0.12)
Use of contraceptive pills 0.58 (0.72) 0.28 (0.83) 0.74 (1.38) 0.35 (1.61) 1.53 (1.61)
Cortisone
Working day 0.37 (0.6) 0.52 (0.68) −1.66 (0.73)* 1.46 (1.13) 0.74 (1.04)
Duration of sleep 0.39 (0.26) 0.24 (0.31) 0.34 (0.33) 0.59 (0.53) 0.05 (0.46)
Time of awakening 0.036 (0.24) 0.3 (0.24) −0.6 (0.24)* 0.6 (0.42) −0.72 (0.36)*
Medication use 0.72 (0.99) 2.37 (1.08)* 3.08 (1.21)* 5.36 (1.85)** 2.97 (1.58)
Smoking −3.09 (1.31)* −4.64 (1.2)** −5.68 (1.53)** −9.1 (2.21)** 2.88 (2.03)
Sex 0.72 (1.12) 1.57 (1.19) 1.92 (1.49) 2.99 (2.26) 1.51 (1.57)
Age 0.04 (0.13) 0.11 (0.14) 0.14 (0.17) 0.17 (0.27) 0.24 (0.17)
Use of contraceptive pills 2.78 (1.66) 3.59 (1.76) 3.11 (2.35) 6.48 (3.39) 0.96 (2.54)

Data are expressed as X2 (SE). AUCi, area under the curve with respect to increase; AUCg, area under the curve with respect to ground.