Table 2.
Hazard ratio of incidence CVD according to N-6 PUFAs.
| N-6 PUFAs | Q1 | Q2 | 95% CI | Q3 | 95% CI | Q4 | 95% CI | P-trend |
|---|---|---|---|---|---|---|---|---|
| Median | 20.99 | 24.61 | 27.15 | 31.22 | ||||
| Case (n) | 136 | 112 | 95 | 81 | ||||
| Person-years | 6466.5 | 6687.1 | 7453.8 | 8277.6 | ||||
| Rates/1000 py | 21 | 16.7 | 12.7 | 9.8 | ||||
| Model 1 | 1 | 0.83 | (0.64, 1.07) | 0.66 | (0.51, 0.87) | 0.52 | (0.39, 0.69) | <0.001 |
| Model 2 | 1 | 0.83 | (0.64, 1.08) | 0.68 | (0.52, 0.89) | 0.51 | (0.38, 0.68) | <0.001 |
| Model 3 | 1 | 0.87 | (0.67, 1.13) | 0.71 | (0.54, 0.94) | 0.52 | (0.38, 0.71) | <0.001 |
| LA | Q1 | Q2 | 95% CI | Q3 | 95% CI | Q4 | 95% CI | p-trend |
| Median | 10.83 | 13.77 | 16.62 | 20.98 | ||||
| Case (n) | 121 | 121 | 107 | 75 | ||||
| Person-years | 6509.1 | 6666.7 | 7476.3 | 8295.5 | ||||
| Rates/1000 py | 18.6 | 18.2 | 14.3 | 9.0 | ||||
| Model 1 | 1 | 1.08 | (0.83, 1.40) | 0.86 | (0.66, 1.13) | 0.56 | (0.41, 0.77) | <0.001 |
| Model 2 | 1 | 1.08 | (0.83, 1.40) | 0.86 | (0.66, 1.13) | 0.57 | (0.42, 0.78) | <0.001 |
| Model 3 | 1 | 1.05 | (0.80, 1.37) | 0.87 | (0.67, 1.15) | 0.56 | (0.40, 0.77) | <0.001 |
| AA | Q1 | Q2 | 95% CI | Q3 | 95% CI | Q4 | 95% CI | p-trend |
| Median | 2.02 | 2.62 | 3.22 | 4.21 | ||||
| Case (n) | 124 | 118 | 91 | 91 | ||||
| Person-years | 6607.2 | 7039.1 | 7471 | 7830.4 | ||||
| Rates/1000 py | 18.8 | 16.8 | 12.2 | 11.6 | ||||
| Model 1 | 1 | 0.91 | (0.70, 1.17) | 0.69 | (0.52, 0.91) | 0.70 | (0.52, 0.92) | 0.004 |
| Model 2 | 1 | 0.94 | (0.73, 1.23) | 0.68 | (0.52, 0.91) | 0.70 | (0.53, 0.94) | 0.005 |
| Model 3 | 1 | 0.95 | (0.73, 1.24) | 0.72 | (0.53, 0.96) | 0.79 | (0.58, 1.07) | 0.06 |
| GLA | Q1 | Q2 | 95% CI | Q3 | 95% CI | Q4 | 95% CI | p-trend |
| Median | 0.12 | 0.17 | 0.23 | 0.32 | ||||
| Case (n) | 107 | 100 | 120 | 97 | ||||
| Person-years | 7085.4 | 7198.9 | 7087.6 | 7575.7 | ||||
| Rates/1000 py | 15.1 | 13.9 | 16.9 | 12.8 | ||||
| Model 1 | 1 | 0.99 | (0.75, 1.32) | 1.23 | (0.94, 1.61) | 0.95 | (0.71, 1.26) | 0.94 |
| Model 2 | 1 | 0.98 | (0.74, 1.31) | 1.17 | (0.89, 1.53) | 0.89 | (0.66, 1.19) | 0.55 |
| Model 3 | 1 | 0.99 | (0.74, 1.32) | 1.19 | (0.90, 1.58) | 0.93 | (0.69, 1.25) | 0.81 |
Model 1: age, gender.
Model 2: Model 1+ body mass index, smoking, alcohol consumption habits, marital status, education level, occupation, and regular exercise.
Model 3: Model 2+ baseline hypertension, diabetes, continuous high-density lipoprotein and low-density lipoprotein cholesterol values.
AA: arachidonic acid; CI: confidence interval; CVD: cardiovascular diseases; GLA: gamma-linolenic acid; LA: linoleic acid; PUFAs: polyunsaturated fatty acids; py: person-years.