Skip to main content
. Author manuscript; available in PMC: 2020 Dec 16.
Published in final edited form as: Dev Cell. 2019 Nov 21;51(6):745–758.e6. doi: 10.1016/j.devcel.2019.10.024

Figure 3.

Figure 3.

Pre-meiotic loss of Gcn5 leads to abnormal spermiogenesis and fertility defects. A) Protein expression of Gcn5 and H3K9ac in germ cells of Gcn5Ctrl (left) and Gcn5cKO (right) mice. B) UCSC Genome Browser track of total ATAC-seq for Gcn5Ctrl and Gcn5cKO cells depicting deletion of Gcn5 in Gcn5cKO (grey box). Loss of Gcn5 leads to decreased testes size (C), testis/body weight ratio (D), and total epididymal sperm (E). Data presented as means+/−SEM (p<0.001). F) Dapi stained Gcn5cKO sperm exhibit abnormal nuclear morphology. G) Abnormal morphology is increased in Gcn5cKO animals (p<0.01). J) Cumulative number of pups born during 5-month breeding trial. H) Representative H&E staining of adult testes. See also Figure S3.