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. Author manuscript; available in PMC: 2020 Dec 16.
Published in final edited form as: Dev Cell. 2019 Nov 21;51(6):745–758.e6. doi: 10.1016/j.devcel.2019.10.024

Figure 5.

Figure 5.

Loss of Gcn5 leads to altered chromatin dynamics and gene expression. Subnucleosomal ATAC-seq at promoters of all genes divided into deciles of RNA expression (0% non-expressed, 100% highest expressed) for M, RS, and ES in (A) Gcn5Ctrl and (B) Gcn5cKO. Statistical analysis performed on first vs last decile by Mann-Whitney rank-sum test. C) Subnucleosomal ATAC-seq signal at promoters of genes increasing in expression between M to RS in Gcn5Ctrl (Mann-Whitney rank-sum test). D) Genes with increased expression in Gcn5Ctrl during M to RS (left) or RS to ES (right) transitions, divided into deciles, exhibit dampened expression in Gcn5cKO cells (y-axis). Gcn5cKO effect is defined as (Gcn5cKO RS/M)/(Gcn5Ctrl RS/M) for M to RS transition (likewise RS to ES). Statistical analysis performed on first vs last decile by Mann-Whitney rank-sum test. See also Figure S4.