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. Author manuscript; available in PMC: 2020 Dec 16.
Published in final edited form as: Dev Cell. 2019 Nov 21;51(6):745–758.e6. doi: 10.1016/j.devcel.2019.10.024

Figure 7.

Figure 7.

Model of nucleosome accessibility during spermiogenesis: Transcriptionally active genes are acetylated in M and RS, prior to replacement by protamines during the transcriptionally quiescent stages of ES and Sp. Nucleosomes evicted in the minor-wave of chromatin accessibility are acetylated in RS (pink) or in the major-wave in ES (yellow) and evicted and replaced by protamines. In the Gcn5cKO mutant model, lack of acetylation leads to loss of chromatin accessibility and diminished minor and major waves, ultimately resulting in increased histone retention in sperm.