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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Clin Genet. 2019 Sep 1;97(1):168–178. doi: 10.1111/cge.13624

TABLE 2.

Included studies by design and date of publication

Total Case report/series Observational: cross sectional Observational: case controlled Observational: cohort
1988 or earlier 21 (20%) 19 (90%) 1 (5%) 1 (5%) 0
1989–1998 16 (15%) 10 (63%) 5 (31%) 1 (6%) 0
1999–2008 20 (19%) 11 (55%) 4 (20%) 5 (25%) 0
2009–2019 48 (46%) 22 (46%) 19 (40%) 5 (10%) 2 (4%)