. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: J Pediatr Adolesc Gynecol. 2019 Jun 21;32(6):605–611. doi: 10.1016/j.jpag.2019.06.005

Table 1.

Included Studies

Reference	Clinical Diagnosis(es)	n	Age at Gonadectomy	AR Sequencing Performed	Germ Cells Present	Precursor Lesions	Malignant Tumors
Morris⁷	Testicular feminization	80	12-51 Years	^*	^*	^*	6/80: Seminoma, alveolar carcinoma, malignant teratoma, pelvic sarcoma, and malignant arrhenoblastoma
Morris and Mahesh^26,†	Testicular feminization	181	Postpubertal	^*	^*	^*	11/50: Seminoma
Dewhurst et al²⁷	Androgen insensitivity (AIS)	82	Before puberty to older than 30 years	^*	^*	^*	0/82
Dewhurst et al¹⁵	AIS, PAIS	66 (44 CAIS; 22 PAIS)	Younger than 15 to older than 30 years	^*	^*	^*	0/44 CAIS; 1/12 PAIS: seminoma
Manuel et al¹⁹	Testicular feminization	23	^*	^*	^*	^*	0/23
Muller²¹	CAIS, IAIS	12 (4 CAIS; 8 IAIS)	2 Months to 19 years	^*	50%	3/12	Carcinoma in situ
Hurt et al²²	AIS	1	14 Years	^*	^*	^*	Seminoma
Rutgers and Scully²³	CAIS, IAIS	43 (40 CAIS; 3 IAIS)	16-83 Years CAIS^‡; 14-47 years PAIS	^*	28% CAIS; 0% PAIS	^*	3/40 CAIS: seminomas and sex cord tumor; 0/3 PAIS
Ahmed et al²⁸	CAIS, PAIS	278 (173 PAIS; 105 CAIS)	14 Years (0.1-18)^§	Yes^‖	^*	^*	0/278
Hannema et al²⁴	CAIS	44	5.5 Years (1-13)^¶	Yes	95%	2/44	Carcinoma in situ
Purves et al²⁵	CAIS	16	18.2 Years (2-21)	^*	^*	^*	0/16
Kravarusic et al¹⁴	CAIS, PAIS	11 (6 CAIS; 5 PAIS)	3-8 Years^‡	^*	^*	^*	0/6 CAIS; 2/5 PAIS: bilateral seminoma, gonadoblastoma
Liu et al¹⁶	Gonadal dysgenesis, CAIS, PAIS	102 (30 CAIS; 18 PAIS)	20.7 Years (16-34)^‡	^*	^*	0/48	9/30 CAIS: gonadoblastoma; 3/18 PAIS: gonadoblastoma
Kaprova-Pleskacova et al¹⁸	CAIS	19 (36 Gonads)	3 Months to 18.5 years^‡	Yes	84%	6/13	Precursor lesion types not reported; 1/13: intratubular germ cell neoplasia
Cools et al³	CAIS, PAIS	52 (42 CAIS; 10 PAIS)	17.5 Years (14-54)^¶	Yes	64% CAIS 88% PAIS	7/52	Precursor lesions types not reported; 0/52 in situ tumors

AIS, androgen insensitivity syndrome; IAIS, incomplete androgen insensitivity syndrome; AR, androgen receptor; CAIS, complete androgen insensitivity syndrome; PAIS, partial androgen insensitivity syndrome.

Not reported or unknown.

^†

Literature review of cases.

^‡

At clinical presentation.

^§

Sixty-six percent of CAIS cases had gonadectomy before puberty, 29% postpubertal, 5% unknown age; 39% of PAIS cases had gonadectomy before puberty, 9% postpubertal, and 52% unknown age.

^‖

In a subset of cases; 51 CAIS, 114 PAIS.

^¶

Median.