Fig. 3.

Il22ra2^−/− mice have decreased inflammation 5 and 10 days after influenza infection. Mice were infected with PR8 (A/PR/8/34, 100 PFU) via oropharyngeal administration. Bronchoalveolar lavage was collected and cells were collected. a Total inflammation from day 5. b Total inflammation from day 10 after infection. c Differential counts from day 5. d Differential counts from day 10. e Ratio of M2/M1 macrophages in wild-type vs. il-22ra2^−/− mice. f Cytokine analysis for IL-6, IL-17, Ifnγ, and RANTES from lung homogenate. n = 8 mice from two independent experiments for a–d. Statistical analysis was performed using one-way ANOVA with Tukey’s post hoc test or Student’s T test (e). *p < 0.05, **p < 0.01, and ****p < 0.0001