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Unique features of the DiffStat instrument that should prove useful in bioanalysis. A) Faradaic current cancellation was shown possible by adding labeled analyte to both W1 and W2, sequentially. The initial faradaic peak increase at W1 (blue) was cancelled by adding MB-DNA also to W2, thereby subtracting the current back to zero (red) in real time. B) A signal-OFF assay could be transformed to a signal-ON assay using a similar concept, with appropriate choice of W2.
