Table 4.
Associations of CRP with metabolites in the discovery (WHI-HT) and replication (WHI-OS) datasets1,2,3,4
| HMDB # | Associations in WHI-HT (discovery, n=1109) | Associations in WHI-OS (replication, n=810) | |||
|---|---|---|---|---|---|
| Metabolite | Beta estimate (95%CI) | FDR-adjusted P-value | Beta estimate (95%CI) | FDR –adjusted P-value | |
| Trigonelline | HMDB0000875 | −0.09 (−0.13, −0.04) | 2.96 E-04 | −0.004 (−0.05, 0.04) | 0.867 |
| Caffeine | HMDB0001847 | 0.01 (−0.04, 0.05) | 0.767 | 0.08 (0.04, 0.13) | 9.67 E-04 |
| 5-acetylamino-6-amino-3-methyluracil | HMDB0004400 | −0.02 (−0.06, 0.03) | 0.431 | −0.01 (−0.06, 0.03) | 0.603 |
| 7-methylxanthine | HMDB0001991 | −0.02 (−0.07, 0.02) | 0.341 | −0.02 (−0.06, 0.03) | 0.477 |
| 1,7-dimethyluric acid | HMDB0011103 | 0.01 (−0.04, 0.05) | 0.673 | 0.07 (0.02, 0.12) | 0.007 |
| 3-methylxanthine | HMDB0001886 | −0.01 (−0.06, 0.04) | 0.708 | 0.01 (−0.04, 0.06) | 0.642 |
| C52:3 TAG | HMDB0005384 | 0.07 (0.02, 0.12) | 0.012 | 0.06 (0.02, 0.11) | 0.005 |
| Linoleate | HMDB0000673 | 0.08 (0.03, 0.13) | 0.004 | 0.02 (−0.02, 0.07) | 0.307 |
| C18:3 CE | HMDB0010370 | −0.07 (−0.11, −0.02) | 0.007 | −0.02 (−0.07, 0.02) | 0.339 |
| Glycine | HMDB0000123 | −0.18 (−0.23, −0.14) | 1.58 E-13 | −0.14 (−0.18, −0.10) | 1.72 E-09 |
| Isoleucine | HMDB0000172 | 0.12 (0.08, 0.16)) | 8.32 E-07 | 0.04 (−0.002, 0.09) | 0.062 |
| Uracil | HMDB0000300 | −0.02 (−0.07, 0.02) | 0.314 | −0.06 (−0.10, −0.01) | 0.011 |
| C18:3 LPC | HMDB0010387 | −0.18 (−0.23, −0.13) | 2.65 E-11 | −0.10 (−0.14, −0.05) | 2.33 E-05 |
| C24:0 LPC | HMDB0008038 | −0.16 (−0.20, −0.11) | 3.82 E-10 | −0.12 (−0.16, −0.08) | 5.59 E-08 |
| Sebacate | HMDB0000792 | −0.05 (−0.10, −0.001) | 0.047 | 0.03 (−0.01, 0.08) | 0.158 |
| C34:0 PS | HMDB0012356 | −0.04 (−0.09, 0.003) | 0.069 | 0.03 (−0.02, 0.08) | 0.202 |
| C12 carnitine | HMDB0002250 | 0.03 (−0.01, 0.08) | 0.152 | 0.01 (−0.04, 0.06) | 0.665 |
| C12:1 carnitine | HMDB0013326 | 0.07 (0.02, 0.12) | 0.005 | 0.02 (−0.02, 0.07) | 0.300 |
| C14:1 carnitine | HMDB0002014 | 0.06 (0.01, 0.10) | 0.024 | 0.01 (−0.04, 0.06) | 0.703 |
| C14:2 carnitine | HMDB0013331 | 0.03 (−0.02, 0.08) | 0.187 | 0.01 (−0.04, 0.05) | 0.785 |
| Cortisol | HMDB0000063 | −0.02 (−0.07, 0.03) | 0.462 | 0.002 (−0.04, 0.05) | 0.932 |
| C56:5 TAG | HMDB0005406 | −0.05 (−0.10, 0.002) | 0.058 | −0.01 (−0.04, 0.05) | 0.699 |
| C56:8 TAG | HMDB0005392 | 0.02 (−0.03, 0.07) | 0.407 | −0.02 (−0.06, 0.01) | 0.212 |
1
All values are beta estimates obtained from multivariable-adjusted linear regression modeling 5-unit increments of CRP levels as the main predictor of interest and metabolite as the main response variable of interest.
2
Metabolites in bold font are the 10 replicated metabolites
3
Models were adjusted for body mass index (continuous) age, physical activity, educational level, race/ethnicity, aspirin/NSAIDs use, smoking status, WHI Hormone Therapy trial arm, CHD case-control status.
4
Statistical significance was defined as false-discovery rate adjusted p<0.05.