Table 2.

Bayesian network analysis results

OlinkID	Gene symbol	Classification	FMD log2(FC)
OID01056	INPPL1	Downstream	0.33
OID01304	CRTAC1	Independent	−0.29
OID01133	CD2AP	Upstream	0.43
OID01389	PODXL2	Upstream	0.14
OID01399	TACC3	Upstream	0.25

Bayesian network classification of the five validated FMD signature proteins which were found to be genetically regulated. In the 4th column we further report our estimated log2-fold change (log2-FC) in protein levels between FMD cases and healthy controls. By ‘classification’ according to this Bayesian analysis, ‘downstream’ implies that regulation of this protein is a consequence and not a cause of FMD, ‘independent’ implies a common latent factor simultaneously influences the protein level and disease status, while ‘upstream’ suggests that the protein may potentially be causal for FMD.