Table 2.
Pharmacokinetic parameters of DTX solution, DTX‐5C(Et)‐TG emulsion, DTX‐5C‐TG emulsion, DTX emulsion, and DTX‐S‐S‐TG emulsion after oral administration in rats (mean ± S.D. n = 5)
| Formulations | t max [h] | C max [ng mL−1] | t 1/2 [h] | AUC(0−24 h) | F rel [%] | F ab [%] |
|---|---|---|---|---|---|---|
| DTX Solution | 0.5 ± 0.6 | 21.0 ± 6.9 | 11.9 ± 8.5 | 167.8 ± 125.1 | 100.0 | 9.4 |
| DTX emulsion | 0.5 ± 0.6 | 18.5 ± 17.2 | 12.4 ± 8.5 | 119.9 ± 111.7 | 71.4 | 6.7 |
| DTX‐5C‐TG | 2.8 ± 3.3 | 19.0 ± 4.9 | 12.5 ± 4.1 | 176.8 ± 101.3 | 105.3 | 9.9 |
| DTX‐5C(Et)‐TG | 6.0 ± 10.0 | 25.0 ± 11.8 | 25.2 ± 20.3 | 248.8 ± 111.4 | 148.3 | 14.0 |
| DTX‐S‐S‐TG | 1.7 ± 0.5 | 235.5 ± 120.3 | 8.7 ± 9.0 | 789.9 ± 221.2 | 470.7 | 44.3 |