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. 2019 Oct 24;9(11):246. doi: 10.3390/metabo9110246

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Functional outcome measures during machine perfusion of steatotic livers. NMP of steatotic livers resulted in evidence of higher metabolic activity as expected compared to SNMP. Venous lactate content (a) decreased during three hours of perfusion in both groups but at a fast rate during NMP. ALT (b) is qualitatively higher in steatotic livers during NMP compared to SNMP but did not reach significance. Glucose content in the perfusate (c) was significantly higher during NMP. Steatotic livers produced comparable volumes of bile during the first 2 h of perfusion, but production was significantly higher by the third hour compared to SNMP (d) Data shown as mean ± SEM, * indicates p < 0.05. NMP, normothermic machine perfusion; SNMP, subnormothermic machine perfusion; ALT, alanine aminotransferase.