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. 2019 Oct 24;9(11):246. doi: 10.3390/metabo9110246

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Energy cofactor changes during NMP and SNMP of steatotic livers. (a) ATP:ADP, (b) ATP:AMP, and (c) energy charge ratios at each hour of perfusion. Given the lower metabolic activity at subnormothermic temperatures, steatotic livers are able to regenerate ATP and energy charge to higher levels with oxygenated perfusion compared to NMP. Energy charge was calculated as (ATP + ADP*0.5)/(ATP + ADP + AMP). Within group comparisons at 60, 120, and 180 min are made to a pre-perfusion measurement (time = 0 min). * indicates p < 0.05 for random intercept mixed model comparison of longitudinal data to pre-perfusion levels. Data shown are mean ± SEM. NMP, normothermic machine perfusion; SNMP, subnormothermic machine perfusion.